Association Between Serum Uric Acid Level and Metabolic Syndrome
Open Access
- 31 May 2012
- journal article
- Published by Korean Society for Preventive Medicine in Journal of Preventive Medicine & Public Health
- Vol. 45 (3), 181-187
- https://doi.org/10.3961/jpmph.2012.45.3.181
Abstract
Serum uric acid levels have been reported to be associated with a variety of cardiovascular conditions. However, the direct association between uric acid levels and metabolic syndrome remains controversial. Thus, we evaluated the association of serum uric acid levels and metabolic syndrome in a community-based cohort study in Korea. We performed cross-sectional analysis of baseline data of 889 males and 1491 females (aged 38 to 87) who participated in baseline examinations of the Korean Genome and Epidemiology Study: Kanghwa study. Blood samples were collected after at least an 8 hour fast. Uric acid quartiles were defined as follows: <4.8, 4.8-<5.6, 5.6-<6.5, ≥6.5 mg/dL in males; and <3.8, 3.8-<4.3, 4.3-<5.1, ≥5.1 mg/dL in females. Metabolic syndrome was defined by the National Cholesterol Education Program Adult Treatment Panel III Criteria with adjusted waist circumference cutoffs (90 cm for males; 80 cm for females). The association between serum uric acid quartiles and metabolic syndrome was assessed using multivariate logistic regression. The odds ratio for having metabolic syndrome in the highest versus lowest quartiles of serum uric acid levels was 2.67 (95% confidence interval [CI], 1.60 to 4.46) in males and 2.14 (95% CI, 1.50 to 3.05) in females after adjusting for age, smoking, alcohol intake, body mass index, total cholesterol, HbA1c, albumin, γ-glutamyltransferase, blood urea nitrogen, and log C-reactive protein. The number of metabolic abnormalities also increased gradually with increasing serum uric acid levels (adjusted p for trend < 0.001 in both sexes). Higher serum uric acid levels are positively associated with the presence of metabolic syndrome in Korean males and females.Keywords
This publication has 24 references indexed in Scilit:
- Increasing Prevalence of Metabolic Syndrome in KoreaDiabetes Care, 2011
- Relationship Between Serum Uric Acid Levels, Metabolic Syndrome, and Arterial Stiffness in KoreanKorean Circulation Journal, 2010
- Uric Acid and Cardiovascular RiskThe New England Journal of Medicine, 2008
- Prevalence of the Metabolic Syndrome in Individuals with HyperuricemiaAmerican Journal Of Medicine, 2007
- Association Between Serum Uric Acid Level and Components of the Metabolic SyndromeJournal of the Chinese Medical Association, 2006
- Serum Uric Acid Is a Determinant of Metabolic Syndrome in a Population-Based StudyAmerican Journal of Hypertension, 2006
- Spousal Concordance of Metabolic Syndrome in 3141 Korean Couples: A Nationwide SurveyAnnals of Epidemiology, 2006
- Diagnosis and Management of the Metabolic SyndromeCirculation, 2005
- Changes in the Characteristics of Metabolic Syndrome in Korea Over the Period 1998–2001 as Determined by Korean National Health and Nutrition Examination SurveysDiabetes Care, 2005
- Association Between Serum Uric Acid, Metabolic Syndrome, and Carotid Atherosclerosis in Japanese IndividualsArteriosclerosis, Thrombosis, and Vascular Biology, 2005