Sizing Nanomatter in Biological Fluids by Fluorescence Single Particle Tracking
- 5 October 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 10 (11), 4435-4442
- https://doi.org/10.1021/nl103264u
Abstract
Accurate sizing of nanoparticles in biological media is important for drug delivery and biomedical imaging applications since size directly influences the nanoparticle processing and nanotoxicity in vivo. Using fluorescence single particle tracking we have succeeded for the first time in following the aggregation of drug delivery nanoparticles in real time in undiluted whole blood. We demonstrate that, by using a suitable surface functionalization, nanoparticle aggregation in the blood circulation is prevented to a large extent.Keywords
This publication has 36 references indexed in Scilit:
- What the Cell “Sees” in BionanoscienceJournal of the American Chemical Society, 2010
- Size and shape effects in the biodistribution of intravascularly injected particlesJournal of Controlled Release, 2009
- Nanoparticles for biomedical imagingExpert Opinion on Drug Delivery, 2009
- Understanding biophysicochemical interactions at the nano–bio interfaceNature Materials, 2009
- Nanoparticle size and surface properties determine the protein corona with possible implications for biological impactsProceedings of the National Academy of Sciences, 2008
- Particle size-dependent triggering of accelerated blood clearance phenomenonInternational Journal of Pharmaceutics, 2008
- Nanoparticles for drug delivery: The need for precision in reporting particle size parametersEuropean Journal of Pharmaceutics and Biopharmaceutics, 2008
- Nucleic acid delivery: Where material sciences and bio-sciences meetMaterials Science and Engineering: R: Reports, 2007
- Drug Delivery Systems: Entering the MainstreamScience, 2004
- The size of liposomes: a factor which affects their targeting efficiency to tumors and therapeutic activity of liposomal antitumor drugsAdvanced Drug Delivery Reviews, 1999