Bioactive glass microspheres as reinforcement for improving the mechanical properties and biological performance of poly(ε‐caprolactone) polymer for bone tissue regeneration
- 25 January 2012
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Vol. 100B (4), 967-975
- https://doi.org/10.1002/jbm.b.32659
Abstract
This study examined the utility of sol–gel-derived bioactive glass microspheres (BGMs) as a reinforcement to improve the mechanical properties and biological performance of poly(ε-caprolactone) (PCL) polymer. All of the PCL-BGMs composites produced, with a variety of BGMs contents (10, 20, and 30 wt %), showed a uniform distribution of the BGMs in the PCL matrix, particularly owing to their spherical shape and small size. This led to a considerable increase in the elastic modulus from 93 ± 12 MPa to 635 ± 179 MPa with increasing BGMs content from 0 to 30 wt %. Furthermore, the addition of the BGMs to the PCL polymer significantly increased the hydrophilicity of the PCL-BGMs composites, which led to a higher water absorption and degradation rate. The PCL-BGMs composite with a BGMs content of 30 wt % showed vigorous growth of apatite crystals with a high aspect ratio on its surface after soaking in the simulated body fluid for 7 days, resulting in the creation of a porous carbonate hydroxyapatite layer. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.Keywords
This publication has 40 references indexed in Scilit:
- Synthesis and in vitro bioactivity of novel mesoporous hollow bioactive glass microspheresMaterials Letters, 2009
- Effects of the reinforcement morphology on the fatigue properties of hydroxyapatite reinforced polymersJournal of the Mechanical Behavior of Biomedical Materials, 2008
- Antibiotic-loaded poly-ε-caprolactone and porous β-tricalcium phosphate composite for treating osteomyelitisBiomaterials, 2008
- In Vivo Behavior of Poly(∈-Caprolactone-co-DL-Lactide)/Bioactive Glass Composites in Rat Subcutaneous TissueJournal of Bioactive and Compatible Polymers, 2007
- Processing Methods of Ultrathin Poly(ε-caprolactone) Films for Tissue Engineering ApplicationsBiomacromolecules, 2007
- Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibersBiomaterials, 2004
- Development of guided bone regeneration membrane composed of β-tricalcium phosphate and poly (l-lactide-co-glycolide-co-ε-caprolactone) compositesBiomaterials, 2004
- Third-Generation Biomedical MaterialsScience, 2002
- Structural Evolution of Alkoxide Silica Gels to Glass: Effect of Catalyst pHJournal of the American Ceramic Society, 1993
- Surface-Active BiomaterialsScience, 1984