Development of guided bone regeneration membrane composed of β-tricalcium phosphate and poly (l-lactide-co-glycolide-co-ε-caprolactone) composites
- 5 March 2004
- journal article
- Published by Elsevier BV in Biomaterials
- Vol. 25 (28), 5979-5986
- https://doi.org/10.1016/j.biomaterials.2004.02.001
Abstract
To create biodegradable and thermoplastic materials for guided bone regeneration, GBR, and guided tissue regeneration, GTR, membranes, composites of β-tricalcium phosphate, TCP, and biodegradable polyesters, poly (l-lactide-co-glycolide-co-ε-caprolactone), PLGC, and poly (l-lactide-co-ε-caprolactone), PLCL, were prepared by a heat-kneading method. The composites maintained thermoplasticity and mechanical strength by formation of a chemical interaction between Ca on TCP and CO on the lactide segment of PLGC or PLCL. The composites also indicated composite effects in pH auto-regulation property and elongation of biodegradation period, e.g., the composites maintained their mechanical strength up to 12 weeks after soaking in both physiological and phosphate-buffered saline, and the period was sufficient time to use for GBR and GTR membranes. Animal tests for GBR indicated that the present composite membrane successfully regenerated beagles’ mandible defects 10×10×10 mm3 in size. These results suggested that the TCP/PLGC bioresorbable composites could be utilized for GBR and GTR therapy.Keywords
This publication has 19 references indexed in Scilit:
- In vitro change in mechanical strength of β‐tricalcium phosphate/copolymerized poly‐L‐lactide composites and their application for guided bone regenerationJournal of Biomedical Materials Research, 2002
- Comparative study of three different membranes for guided bone regeneration of rat cranial defectsInternational Journal of Oral & Maxillofacial Surgery, 2001
- Chemical Interaction in .BETA.-Tricalcium Phosphate/Copolymerized Poly-L-Lactide Composites.Journal of the Ceramic Society of Japan, 2000
- Bioresorbable devices made of forged composites of hydroxyapatite (HA) particles and poly-?-lactide (PLLA): Part I. Basic characteristicsBiomaterials, 1999
- Evaluation of guided bone regeneration in rabbit tibia using bioresorbable and non-resorbable membranesBiomaterials, 1996
- Histological evaluation of a biodegradable polyactive®/ hydroxyapatite membraneBiomaterials, 1995
- Guided bone regeneration in mandibular defects in rats using a bioresorbable polymerClinical Oral Implants Research, 1994
- Immediate implant placement using a biodegradable barrier, polyhydroxybutyrate‐hydroxyvalerate reinforced with polyglactin 910. An experimental study in dogs.Clinical Oral Implants Research, 1994
- Augmentation of the rat mandible using guided tissue regenerationClinical Oral Implants Research, 1994
- BONE REGENERATION GUIDED BY RESORBABLE COLLAGEN MEMBRANES IN RABBITSImplant Dentistry, 1993