Boron‐Catalyzed N‐Alkylation of Amines using Carboxylic Acids
- 6 July 2015
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 54 (31), 9042-9046
- https://doi.org/10.1002/anie.201503879
Abstract
A boron-based catalyst was found to catalyze the straightforward alkylation of amines with readily available carboxylic acids in the presence of silane as the reducing agent. Various types of primary and secondary amines can be smoothly alkylated with good selectivity and good functional-group compatibility. This metal-free amine alkylation was successfully applied to the synthesis of three commercial medicinal compounds, Butenafine, Cinacalcet. and Piribedil, in a one-pot manner without using any metal catalysts.Keywords
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