Metal-Free Borane-Catalyzed Highly Stereoselective Hydrogenation of Pyridines
- 14 August 2013
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 135 (35), 12968-12971
- https://doi.org/10.1021/ja406761j
Abstract
A metal-free direct hydrogenation of pyridines was successfully realized by using homogeneous borane catalysts generated from alkenes and HB(C6F5)2 via in situ hydroboration. The reaction affords a broad range of piperidines in high yields with excellent cis stereoselectivities.Keywords
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