Advances in male hormonal contraception
Open Access
- 21 March 2006
- journal article
- review article
- Published by Taylor & Francis Ltd in Expert Opinion on Investigational Drugs
- Vol. 15 (4), 389-397
- https://doi.org/10.1517/13543784.15.4.389
Abstract
There is a need to develop new contraceptives, particularly for men whose current choices are suboptimal in terms of effectiveness and ease of reversibility. Recent surveys indicate that men and their partners would be willing to rely on male hormonal contraceptives. Male hormonal contraception works by reversibly suppressing sperm production. Testosterone in combination with progestins or gonadotropin-releasing hormone antagonists induces profound and consistent sperm suppression. Asian men are more susceptible to the suppressive effects of testosterone given alone, even if they may benefit from the addition of an adjunctive agent to obtain optimal contraceptive protection. The aim of this review is to comment on the recent relevant achievements in the field.Keywords
This publication has 43 references indexed in Scilit:
- Intramuscular Testosterone Enanthate Plus Very Low Dosage Oral Levonorgestrel Suppresses Spermatogenesis Without Causing Weight Gain in Normal Young Men: A Randomized Clinical TrialJournal of Andrology, 2005
- Hopes for male contraceptionThe Lancet, 2005
- Progress towards hormonal male contraceptionTrends in Pharmacological Sciences, 2004
- Sixth Summit Meeting Consensus: Recommendations for Regulatory Approval for Hormonal Male ContraceptionInternational Journal of Andrology, 2002
- Effects of Testosterone Plus Medroxyprogesterone Acetate on Semen Quality, Reproductive Hormones, and Germ Cell Populations in Normal Young MenJournal of Clinical Endocrinology & Metabolism, 2002
- An Effective Hormonal Male Contraceptive Using Testosterone Undecanoate with Oral or Injectable Norethisterone PreparationsJournal of Clinical Endocrinology & Metabolism, 2002
- Combination of subcutaneous levonorgestrel implants and transdermal dihydrotestosterone gel for male hormonal contraceptionInternational Journal of Andrology, 2001
- A Clinical Trial of Injectable Testosterone Undecanoate as a Potential Male Contraceptive in Normal Chinese MenJournal of Clinical Endocrinology & Metabolism, 1999
- Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: a promising male contraceptive approachJournal of Clinical Endocrinology & Metabolism, 1996
- Contraceptive efficacy of testosterone-induced azoospermia in normal menThe Lancet, 1990