Hepatitis E Virus Replication Requires an Active Ubiquitin-Proteasome System
- 15 May 2012
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 86 (10), 5948-5952
- https://doi.org/10.1128/jvi.07039-11
Abstract
The mechanism of hepatitis E virus (HEV) replication remains largely unknown. Here we demonstrate that HEV replication requires an active ubiquitin-proteasome system and that proteasome inhibitors affect HEV replication, possibly by inhibition of viral transcription or/and translation without a significant effect on cellular translation. Overexpression of ubiquitin in inhibitor-treated cells partially reverses the inhibitor effect on HEV replication. The results suggest that HEV replication requires interactions with proteasome machinery, which could be a potential therapeutic target against HEV.This publication has 47 references indexed in Scilit:
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