A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine
- 3 December 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in Psychopharmacology
- Vol. 203 (4), 703-711
- https://doi.org/10.1007/s00213-008-1417-z
Abstract
We previously colocalized a quantitative trait locus (QTL) for sensitivity to the locomotor stimulant effects of methamphetamine (MA) with a QTL for expression of casein kinase 1 epsilon (Csnk1-ɛ) in the nucleus accumbens (NAc). Subsequently, we identified a single nucleotide polymorphism in CSNK1E (rs135745) that was associated with increased sensitivity to the subjective effects of d-amphetamine in healthy human subjects. Based on these results, we hypothesized that differential expression of Csnk1-ɛ causes differential sensitivity to MA-induced locomotor activity in mice.Keywords
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