CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling
Open Access
- 15 February 2006
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 20 (4), 399-410
- https://doi.org/10.1101/gad.1394306
Abstract
Multiple members of the casein kinase I family of serine/threonine protein kinases are involved in positive and negative roles in Wnt and Hedgehog signaling. Here I review these roles, including recent results on casein kinase I (CKI) phosphorylation and activation of LRP6, and CKI phosphorylation of Ci and mediation of Ci–Slimb/β–TrCP binding.Keywords
This publication has 77 references indexed in Scilit:
- Phosphorylation by Double-Time/CKIε and CKIα Targets Cubitus Interruptus for Slimb/β-TRCP-Mediated Proteolytic ProcessingDevelopmental Cell, 2005
- Wnt signalling in stem cells and cancerNature, 2005
- THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASEAnnual Review of Cell and Developmental Biology, 2004
- Mechanism of Phosphorylation-Dependent Binding of APC to β-Catenin and Its Role in β-Catenin DegradationMolecular Cell, 2004
- Biochemical Characterization of the Drosophila Wingless Signaling Pathway Based on RNA InterferenceMolecular and Cellular Biology, 2004
- Regulation of Casein Kinase Iϵ Activity by Wnt SignalingJournal of Biological Chemistry, 2004
- Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replicationNature, 2001
- Crystal Structure of a Conformation-selective Casein Kinase-1 InhibitorJournal of Biological Chemistry, 2000
- Regulation of β-Catenin Signaling by the B56 Subunit of Protein Phosphatase 2AScience, 1999
- The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitroGenes & Development, 1999