Competition-colonization dynamics in an RNA virus
- 13 January 2010
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 107 (5), 2108-2112
- https://doi.org/10.1073/pnas.0909787107
Abstract
During replication, RNA viruses rapidly generate diverse mutant progeny which differ in their ability to kill host cells. We report that the progeny of a single RNA viral genome diversified during hundreds of passages in cell culture and self-organized into two genetically distinct subpopulations that exhibited the competition-colonization dynamics previously recognized in many classical ecological systems. Viral colonizers alone were more efficient in killing cells than competitors in culture. In cells coinfected with both competitors and colonizers, viral interference resulted in reduced cell killing, and competitors replaced colonizers. Mathematical modeling of this coinfection dynamics predicted selection to be density dependent, which was confirmed experimentally. Thus, as is known for other ecological systems, biodiversity and even cell killing of virus populations can be shaped by a tradeoff between competition and colonization. Our results suggest a model for the evolution of virulence in viruses based on internal interactions within mutant spectra of viral quasispecies.This publication has 60 references indexed in Scilit:
- Hidden Virulence Determinants in a Viral Quasispecies In VivoJournal of Virology, 2008
- THE EFFECTS OF MULTIPLE INFECTIONS ON THE EXPRESSION AND EVOLUTION OF VIRULENCE IN ADAPHNIA‐ENDOPARASITE SYSTEMEvolution, 2008
- Distribution of Fitness and Virulence Effects Caused by Single-Nucleotide Substitutions in Tobacco Etch VirusJournal of Virology, 2007
- Insights into RNA Virus Mutant Spectrum and Lethal Mutagenesis Events: Replicative Interference and Complementation by Multiple Point MutantsJournal of Molecular Biology, 2007
- Molecular Basis for a Lack of Correlation between Viral Fitness and Cell Killing CapacityPLoS Pathogens, 2007
- Increased Fidelity Reduces Poliovirus Fitness and Virulence under Selective Pressure in MicePLoS Pathogens, 2005
- Evolutionary Transition toward Defective RNAs That Are Infectious by ComplementationJournal of Virology, 2004
- Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller’s ratchetJournal of Molecular Biology, 1999
- HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation TimeScience, 1996
- Superinfection, Metapopulation Dynamics, and the Evolution of DiversityJournal of Theoretical Biology, 1994