Effect of the dose volume of perfluorocarbon when starting partial liquid ventilation
- 3 September 2010
- journal article
- research article
- Published by Wiley in Journal of Paediatrics and Child Health
- Vol. 46 (12), 714-722
- https://doi.org/10.1111/j.1440-1754.2010.01828.x
Abstract
Objective: Very preterm neonates are prone to brain injury if cerebral blood flow fluctuates. Partial liquid ventilation (PLV) may benefit any lung disease but giving 30 mL/kg of perfluorocarbon when starting PLV increases cortical cerebral blood flow velocity. We aimed to determine if varying the initial dose of perfluorocarbon alters the effect on cerebral blood flow velocity when starting PLV. Methods: In this randomised, controlled trial with historical comparison 24 preterm lambs received one of three loading doses of intratracheal perfluorocarbon liquid over 20 min when starting PLV: 20, 30 or 40 mL/kg. Data on respiratory mechanics, haemodynamics and cerebral blood flow velocity, measured with laser Doppler, were collected continuously for 30 min from the start of dosing. Results: Cortical cerebral blood flow velocity increased over time in all three groups (two-way ANOVA, P = 0.007). There was no difference between groups (two-way ANOVA, P = 0.26). There was no difference between groups in cortical cerebral blood flow velocity variability (P = 0.68), blood pressure (P = 0.96) or heart rate (P = 0.46). The was no statistically significant difference in PaCO2 between groups measured at baseline and at 30 min after starting PLV (P = 0.51). Conclusions: Cortical cerebral blood flow velocity and its variability are not affected by varying doses of tracheal perfluorocarbon (20, 30 or 40 mL/kg) at the start of PLV in preterm lambs.Keywords
This publication has 28 references indexed in Scilit:
- Perfluorocarbon Dosing when Starting Partial Liquid Ventilation: Haemodynamics and Cerebral Blood Flow in Preterm LambsNeonatology, 2009
- Perflubron dosing affects ventilator-induced lung injury in rats with previous lung injury*Critical Care Medicine, 2007
- The Efficacy of Fluorocarbon, Surfactant, and Their Combination for Improving Acute Lung Injury Induced by Intratracheal Acidified Infant FormulaAnesthesia & Analgesia, 2005
- Efficacy of partial liquid ventilation in improving acute lung injury induced by intratracheal acidified infant formula: Determination of optimal dose and positive end-expiratory pressure levelCritical Care Medicine, 2004
- Developmental changes in cerebral autoregulatory capacity in the fetal sheep parietal cortexJournal Of Physiology-London, 2002
- Effect of Increasing Perfluorocarbon Dose on ˙Va/˙Q Distribution during Partial Liquid Ventilation in Acute Lung InjuryAnesthesiology, 2001
- Liquid ventilationJournal of Paediatrics and Child Health, 1999
- Partial Liquid Ventilation with Perflubron in Premature Infants with Severe Respiratory Distress SyndromeThe New England Journal of Medicine, 1996
- Intraventricular hemorrhage in the preterm infantEarly Human Development, 1996
- Intratracheal perfluorocarbon administration combined with mechanical ventilation in experimental respiratory distress syndromeCritical Care Medicine, 1993