Pharmacogenetic Insights into Codeine Analgesia: Implications to Pediatric Codeine Use
- 9 September 2008
- journal article
- review article
- Published by Taylor & Francis Ltd in Pharmacogenomics
- Vol. 9 (9), 1267-1284
- https://doi.org/10.2217/14622416.9.9.1267
Abstract
Codeine has been used medicinally since the 1800s as an analgesic and antitussive agent. Although very few studies have methodically examined the safety of codeine use in the pediatric age group, it is nonetheless commonly prescribed to children and breastfeeding mothers. Empirical evidence over the last century has suggested variability in the efficacy of codeine, and recent genomic advancements have shed important light on the mechanisms leading to such variability. Aside from evaluating the role of genetic variability in drug-metabolizing enzymes, receptors and transporters, the development of the blood–brain-barrier and the ontogeny of drug-metabolizing enzymes must also be considered in newborns and young children.Funding Information
- Ivey Chair in Molecular Toxicology
This publication has 127 references indexed in Scilit:
- Drug metabolism enzyme expression and activity in primary cultures of human proximal tubular cellsToxicology, 2008
- Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT genePain, 2007
- The Effect of CYP2D6 Polymorphisms on the Response to Pain Treatment for Pediatric Sickle Cell Pain CrisisThe Journal of Pediatrics, 2007
- Carrier-mediated processes at several rat brain interfaces determine the neuropharmacokinetics of morphine and morphine-6-β-d-glucuronideLife Sciences, 2006
- Effects of prenatal cocaine, morphine, or both on postnatal opioid (μ) receptor developmentLife Sciences, 2006
- CYP2D7 splice variants in human liver and brain: Does CYP2D7 encode functional protein?Biochemical and Biophysical Research Communications, 2005
- Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypesLife Sciences, 1995
- Efficacy of cough suppressants in childrenThe Journal of Pediatrics, 1993
- Mu receptor binding of some commonly used opioids and their metabolitesLife Sciences, 1991
- Postoperative morphine infusion in newborn infants: Assessment of disposition characteristics and safetyThe Journal of Pediatrics, 1985