Protumor vs Antitumor Functions of IL-17
Open Access
- 1 October 2009
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 183 (7), 4169-4175
- https://doi.org/10.4049/jimmunol.0901017
Abstract
Inflammation appears to be a necessity for both metastasis and elimination of tumor cells. IL-17, a proinflammatory cytokine produced by Th17 cells, contributes to both the processes by playing a dual role in the antitumor immunity. On one hand, IL-17 promotes an antitumor cytotoxic T cell response leading to tumor regression. On the other hand, by facilitating angiogenesis and egress of tumor cells from the primary focus, IL-17 promotes tumor growth. Thus, the therapeutic application that uses IL-17 needs to be refined by minimizing its protumor functions.Keywords
This publication has 109 references indexed in Scilit:
- Plasticity of CD4+ FoxP3+ T cellsCurrent Opinion in Immunology, 2009
- IL‐17‐producing γδ T cellsEuropean Journal of Immunology, 2009
- Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor MicroenvironmentCancer Cell, 2009
- Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cellsEuropean Journal of Immunology, 2009
- Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T CellsImmunity, 2009
- Late Developmental Plasticity in the T Helper 17 LineageImmunity, 2008
- An overview of IL-17 function and signalingCytokine, 2008
- Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell ProgramsImmunity, 2008
- TGFβ in CancerCell, 2008
- Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainNature, 2003