Resistant starch and exercise independently attenuate weight regain on a high fat diet in a rat model of obesity
Open Access
- 1 January 2011
- journal article
- Published by Springer Science and Business Media LLC in Nutrition & Metabolism
- Vol. 8 (1), 49
- https://doi.org/10.1186/1743-7075-8-49
Abstract
Long-term weight reduction remains elusive for many obese individuals. Resistant starch (RS) and exercise may be useful for weight maintenance. The effects of RS, with or without exercise, on weight regain was examined during relapse to obesity on a high carbohydrate, high fat (HC/HF) diet. Obesity-prone rats were fed ad libitum for 16 weeks then weight reduced on a low fat diet to induce a 17% body weight loss (weight reduced rats). Weight reduced rats were maintained on an energy-restricted low fat diet for 18 weeks, with or without a daily bout of treadmill exercise. Rats were then allowed free access to HC/HF diet containing low (0.3%) or high (5.9%) levels of RS. Weight regain, energy balance, body composition, adipocyte cellularity, and fuel utilization were monitored as rats relapsed to obesity and surpassed their original, obese weight. Both RS and exercise independently attenuated weight regain by reducing the energy gap between the drive to eat and suppressed energy requirements. Exercise attenuated the deposition of lean mass during relapse, whereas its combination with RS sustained lean mass accrual as body weight returned. Early in relapse, RS lowered insulin levels and reduced the deposition of fat in subcutaneous adipose tissue. Exercise cessation at five weeks of relapse led to increased weight gain, body fat, subcutaneous adipocytes, and decreased lean mass; all detrimental consequences to overall metabolic health. These data are the first to show the complimentary effects of dietary RS and regular exercise in countering the metabolic drive to regain weight following weight loss and suggest that exercise cessation, in the context of relapse on a HC/HF diet, may have dire metabolic consequences.Keywords
This publication has 52 references indexed in Scilit:
- Failure to Ferment Dietary Resistant Starch in Specific Mouse Models of Obesity Results in No Body Fat LossJournal of Agricultural and Food Chemistry, 2009
- Regular exercise attenuates the metabolic drive to regain weight after long-term weight lossAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2009
- Effects of exercise training on subcutaneous and visceral adipose tissue in normal- and high-fat diet-fed ratsAmerican Journal of Physiology-Endocrinology and Metabolism, 2009
- Dietary Resistant Starch Increases Hypothalamic POMC Expression in RatsObesity, 2009
- Palatable Foods, Stress, and Energy Stores Sculpt Corticotropin-Releasing Factor, Adrenocorticotropin, and Corticosterone Concentrations after RestraintEndocrinology, 2008
- Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodentsAmerican Journal of Physiology-Endocrinology and Metabolism, 2008
- Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long‐Evans Tokushima Fatty (OLETF) ratsJournal Of Physiology-London, 2008
- Effect of Exercise on 24-Month Weight Loss Maintenance in Overweight WomenArchives of Internal Medicine, 2008
- Leptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuliJCI Insight, 2008
- Bone mineral density and content during weight cycling in female rats: effects of dietary amylase-resistant starchNutrition & Metabolism, 2008