Palatable Foods, Stress, and Energy Stores Sculpt Corticotropin-Releasing Factor, Adrenocorticotropin, and Corticosterone Concentrations after Restraint
- 23 December 2008
- journal article
- other
- Published by The Endocrine Society in Endocrinology
- Vol. 150 (5), 2325-2333
- https://doi.org/10.1210/en.2008-1426
Abstract
Previous studies have shown reduced hypothalamo-pituitary-adrenal responses to both acute and chronic restraint stressors in rats allowed to ingest highly palatable foods (32% sucrose ± lard) prior to restraint. In this study we tested the effects of prior access (7 d) to chow-only, sucrose/chow, lard/chow, or sucrose/lard/chow diets on central corticotropin-releasing factor (CRF) expression in rats studied in two experiments, 15 and 240 min after onset of restraint. Fat depot, particularly intraabdominal fat, weights were increased by prior access to palatable food, and circulating leptin concentrations were elevated in all groups. Metabolite concentrations were appropriate for values obtained after stressors. For unknown reasons, the 15-min experiment did not replicate previous results. In the 240-min experiment, ACTH and corticosterone responses were inhibited, as previously, and CRF mRNA in the hypothalamus and oval nucleus of the bed nuclei of the stria terminalis were reduced by palatable foods, suggesting strongly that both neuroendocrine and autonomic outflows are decreased by increased caloric deposition and palatable food. In the central nucleus of the amygdala, CRF was increased in the sucrose-drinking group and decreased in the sucrose/lard group, suggesting that the consequence of ingestion of sucrose uses different neural networks from the ingestion of lard. The results suggest strongly that ingestion of highly palatable foods reduces activity in the central stress response network, perhaps reducing the feeling of stressors.Keywords
This publication has 73 references indexed in Scilit:
- The Anteroventral Bed Nucleus of the Stria Terminalis Differentially Regulates Hypothalamic-Pituitary-Adrenocortical Axis Responses to Acute and Chronic StressEndocrinology, 2007
- Moderate Neonatal Stress Decreases Within-Group Variation in Behavioral, Immune and HPA Responses in Adult MicePLOS ONE, 2007
- Control of appetitive and aversive taste-reactivity responses by an auditory conditioned stimulus in a devaluation task: A FOS and behavioral analysisLearning & Memory, 2007
- Mapping Brain c‐Fos Immunoreactivity after Insulin‐Induced Voluntary Lard Intake: Insulin‐ and Lard‐Associated PatternsJournal of Neuroendocrinology, 2007
- Association of Amphetamine-Induced Striatal Dopamine Release and Cortisol Responses to Psychological StressNeuropsychopharmacology, 2007
- Effects of portion size on chronic energy intakeInternational Journal of Behavioral Nutrition and Physical Activity, 2007
- c-Fos After Incentive Shifts: Expectancy, Incredulity, and Recovery.Behavioral Neuroscience, 2005
- Does amygdaloid corticotropin‐releasing hormone (CRH) mediate anxiety‐like behaviors? Dissociation of anxiogenic effects and CRH releaseEuropean Journal of Neuroscience, 2004
- Neuropeptides and the Integration of Motor Responses to DehydrationAnnual Review of Neuroscience, 2001
- Neuropeptides and thirst: The temporal response of corticotropin-releasing hormone and neurotensin/neuromedin N gene expression in rat limbic forebrain neurons to drinking hypertonic saline.Behavioral Neuroscience, 1995