Molecular Theranostics: A Primer for the Imaging Professional
- 1 August 2011
- journal article
- review article
- Published by American Roentgen Ray Society in American Journal of Roentgenology
- Vol. 197 (2), 318-324
- https://doi.org/10.2214/ajr.11.6797
Abstract
OBJECTIVE. A theranostic system integrates some form of diagnostic testing to determine the presence of a molecular target for which a specific drug is intended. Molecular imaging serves this diagnostic function and provides powerful means for noninvasively detecting disease. We briefly review the paradigms rooted in nuclear medicine and highlight recent advances in this field. We also explore how nanometer-sized complexes, called nanomedicines, present an excellent theranostic platform applicable to both drug discovery and clinical use. CONCLUSION. For imagers, molecular theranostics represents a powerful emerging platform that intimately couples targeted therapeatic entities with noninvasive imaging that yields information on the presence of defined molecular targets before, during, and after cognate therapy.Keywords
This publication has 61 references indexed in Scilit:
- Partially polymerized liposomes: stable against leakage yet capable of instantaneous release for remote controlled drug deliveryNanotechnology, 2011
- PET/CT without capacity limitations: a Danish experience from a European perspectiveEuropean Radiology, 2011
- Development and applications of photo-triggered theranostic agentsAdvanced Drug Delivery Reviews, 2010
- Nanoparticle-based theranostic agentsAdvanced Drug Delivery Reviews, 2010
- Synthesis and in vitro evaluation of cyclic NGR peptide targeted thermally sensitive liposomeJournal of Controlled Release, 2010
- Self-Assembled Gold Nanoparticle Molecular Probes for Detecting Proteolytic Activity In VivoACS Nano, 2010
- Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugateChemical Communications, 2010
- Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubblesJournal of Controlled Release, 2009
- Recent Trends in Soft-Tissue Infection ImagingSeminars in Nuclear Medicine, 2009
- Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug developmentEuropean Journal of Clinical Pharmacology, 2003