Photodynamic Activity of C70 Caged within Surface‐Cross‐Linked Liposomes
- 23 December 2008
- journal article
- research article
- Published by Wiley in Chemistry – An Asian Journal
- Vol. 4 (1), 199-205
- https://doi.org/10.1002/asia.200800271
Abstract
[70]Fullerene (C70) encapsulated into a surface‐cross‐linked liposome, a so‐called cerasome, was prepared by an exchange reaction incorporating C70⋅γ‐cyclodextrin complexes into lipid membranes. Fullerene exchange in a cerasome‐incorporated C70 (CIC70), as well as in a lipid‐membrane‐incorporated C70 (LMIC70), was completed within 1 min with stirring at 25 °C. CIC70 was more resistant to lysis than LMIC70 towards lysing agents such as surfactants. Furthermore, the photodynamic activity of CIC70 in HeLa cells was similar to that of LMIC70, indicating that C70 can act as a photosensitizing drug (PS) without release from cerasome membranes. Thus, in contrast with general drug‐delivery systems (DDSs), which require the drug to be released from the interior of liposomes, carriers for PSs for use in photodynamic therapy (PDT) do not necessarily need to release the drug. These results indicate that DDSs with high morphological stability can increase the residence time in blood and achieves tumor‐selective drug delivery by the enhanced permeability and retention (EPR) effect.Keywords
This publication has 27 references indexed in Scilit:
- Solubilisation of [60]fullerenes using block copolymers and evaluation of their photodynamic activitiesOrganic & Biomolecular Chemistry, 2008
- Induction of cell death by photodynamic therapy with water-soluble lipid-membrane-incorporated [60]fullereneOrganic & Biomolecular Chemistry, 2007
- Cerasome as an Infusible, Cell-Friendly, and Serum-Compatible Transfection Agent in a Viral SizeJournal of the American Chemical Society, 2006
- Efficient photocleavage of DNA utilising water-soluble lipid membrane-incorporated [60]fullerenes prepared using a [60]fullerene exchange methodOrganic & Biomolecular Chemistry, 2005
- Recent advances with liposomes as pharmaceutical carriersNature Reviews Drug Discovery, 2005
- Drug Delivery Systems: Entering the MainstreamScience, 2004
- Photodynamic therapy for cancerNature Reviews Cancer, 2003
- Supramolecular Materials via Polymerization of Mesophases of Hydrated AmphiphilesChemical Reviews, 2002
- Photodynamic Therapy in Oncology: Mechanisms and Clinical UseJNCI Journal of the National Cancer Institute, 1993
- PHOTODYNAMIC THERAPY OF MALIGNANT TUMOURSThe Lancet, 1972