Long-Term Risk of Recurrent Stroke in Young Cryptogenic Stroke Patients with and without Patent Foramen Ovale
- 6 October 2011
- journal article
- Published by SAGE Publications in International Journal of Stroke
- Vol. 7 (8), 631-634
- https://doi.org/10.1111/j.1747-4949.2011.00641.x
Abstract
Background Among patients with a patent foramen ovale and cryptogenic ischemic stroke, the long-term prognosis is unclear. Aims This study aims to estimate the recurrence rate in young cryptogenic stroke patients with and without patent foramen ovale. Patients and methods One hundred eighty-six cryptogenic stroke patients (aged 18–45 years) were prospectively followed for up to five-years. They were divided into two groups according to the echocardiographic presence of patent foramen ovale. All patients received aspirin (100mg/day) for secondary prevention. Results Mean age was 32·3 (standard deviation 7·9) years. During the mean follow-up of 66 months five patients with patent foramen ovale had recurrent strokes compared with 11 patients without patent foramen ovale. The average annual rate of recurrent cerebral ischemia was 1·1% and 1·6% for patients with and without patent foramen ovale, respectively. The recurrence rate did not increase with the presence of patent foramen ovale, atrial septal aneurysm or other variables. More than 60% of the reported cases achieved a good functional outcome. Conclusions Young patients with cryptogenic ischemic stroke with and without patent foramen ovale have a low recurrence rate in a long-term follow-up and most present a favorable outcome. Patent foramen ovale with or without atrial septal aneurysm did not increase the risk of recurrence.Keywords
This publication has 19 references indexed in Scilit:
- Current Management and Risk of Recurrent Stroke in Cerebrovascular Patients with Right-to-Left Cardiac ShuntCerebrovascular Diseases, 2009
- Patent foramen ovale and ischemic stroke recurrenceNeurology, 2009
- Cryptogenic stroke and patent foramen ovale: Clinical clues to paradoxical embolismJournal of the Neurological Sciences, 2008
- Recurrent Stroke and Massive Right-to-Left ShuntStroke, 2008
- Clinical and Imaging Findings in Cryptogenic Stroke Patients With and Without Patent Foramen OvaleStroke, 2002
- Recurrent Cerebrovascular Events Associated with Patent Foramen Ovale, Atrial Septal Aneurysm, or BothNew England Journal of Medicine, 2001
- Recurrent cerebrovascular events in patients with patent foramen ovale, atrial septal aneurysm, or both and cryptogenic stroke or transient ischemic attackAmerican Heart Journal, 1995
- Long-term risk of recurrent stroke after a first-ever stroke. The Oxfordshire Community Stroke Project.Stroke, 1994
- Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.Stroke, 1993
- Paradoxical Cerebral Embolism with a Patent Foramen ovaleCerebrovascular Diseases, 1991