Long-term risk of recurrent stroke after a first-ever stroke. The Oxfordshire Community Stroke Project.
- 1 February 1994
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 25 (2), 333-337
- https://doi.org/10.1161/01.str.25.2.333
Abstract
There have been few community-based studies of long-term prognosis after acute stroke. This study aims to provide precise estimates of the absolute and relative risks of stroke recurrence in an unselected cohort of patients with a first-ever stroke. Six hundred seventy-five patients were registered in a community-based stroke register (the Oxfordshire Community Stroke Project) and prospectively followed for up to 6.5 years. Their relative risk of recurrent stroke was calculated using age- and sex-specific incidence rates for first stroke in Oxfordshire. One hundred eighty recurrent episodes of stroke were identified, of which 135 were first recurrences. Given survival, the actuarial risk of suffering a recurrence was 30% (95% confidence interval, 20% to 39%) by 5 years, about nine times the risk of stroke in the general population. The risk was highest early after the first stroke: 13% (95% confidence interval, 10% to 16%) by 1 year, 15 times the risk in the general population. After the first year the average annual risk was about 4%. The risk of stroke recurrence did not appear to be related to age or pathological type of stroke. The absolute and relative risks of recurrent stroke are highest early after the first stroke but remain elevated for several years thereafter. Efforts at secondary prevention should be initiated as soon as possible and continued for several years to gain greatest benefit.This publication has 17 references indexed in Scilit:
- Swedish Aspirin Low-dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic eventsThe Lancet, 1991
- The prognosis of hospital-referred transient ischaemic attacks.Journal of Neurology, Neurosurgery & Psychiatry, 1991
- Comparison of case ascertainment by medical record linkage and cohort follow-up to determine incidence rates for transient ischemic attacks and strokeJournal of Clinical Epidemiology, 1990
- Mood disorders in long-term survivors of stroke: associations with brain lesion location and volumePsychological Medicine, 1990
- Blood pressure, stroke, and coronary heart disease *1Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution biasThe Lancet, 1990
- A prospective study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project--1981-86. 2. Incidence, case fatality rates and overall outcome at one year of cerebral infarction, primary intracerebral and subarachnoid haemorrhage.Journal of Neurology, Neurosurgery & Psychiatry, 1990
- Results of the seven-year prospective study of stroke patients.Stroke, 1988
- The Prognosis for Patients with Cerebrovascular Stroke and Transient Ischemic AttacksUpsala Journal of Medical Sciences, 1981
- Natural History of Stroke in Rochester, Minnesota, 1955 Through 1969: An Extension of a Previous Study, 1945 Through 1954Stroke, 1973