Free amino acids in plasma and muscle during 24 hours post‐operatively – a descriptive study
- 1 March 1992
- journal article
- research article
- Published by Wiley in Clinical Physiology and Functional Imaging
- Vol. 12 (2), 163-177
- https://doi.org/10.1111/j.1475-097x.1992.tb00303.x
Abstract
Intracellular amino acids in skeletal muscle show a specific concentration pattern on the third post-operative day. The temporal development of these changes has not been clarified. Here the amino acid concentrations in skeletal muscle were studied during the first post-operative day in fourteen patients undergoing elective abdominal surgery. Muscle amino acids were determined pre-operatively, as well as at 12 and 24 h post-operatively. In muscle the concentrations of glutamine and the basic amino acids decreased gradually during the first 24 h after surgery to 79% (P less than 0.001) and 67% (P less than .001) respectively. The sum of the essential amino acids decreased to 73% (P less than 0.001) at 12 h, but thereafter rose to 91% (P less than 0.05) at 24 h. The sum of the BCAA decreased to 84% (P less than 0.05) at 12 h but then increased to 116% (P less than 0.05) at 24 h. The alanine concentration increased to 122% (P less than 0.001) during the first post-operative day. In plasma the alanine concentration increased at 12 h while most other amino acids declined. At 24 h post-operatively the plasma concentrations of all amino acids had returned to normal or showed a tendency towards normalization except for phenylalanine, which increased. At the end of the first post-operative day the concentrations of amino acids in muscle were consistent with the alterations previously observed three days after surgery. The changes in plasma amino acid concentrations only partly reflected those in muscle.Keywords
This publication has 27 references indexed in Scilit:
- Nitrogen sparing effect of ornicetil® in the immediate post-operative state—Plasma and muscle amino-acidsClinical Nutrition, 1987
- Effects of starvation on plasma and muscle amino acid concentrations in normal subjects : E. Vinnars, J. Bergström, P. Fürst. Department of Anaesthesia and Intensive Care, St. Göran's Hospital, Stockholm and Department of Renal Medicine, Huddinge Hospital, Huddinge, SwedenClinical Nutrition, 1987
- The effect of stress hormones upon the intracellular concentrations of free amino acids in human skeletal muscle : J. Wernerman, D. Botta, M.R. Ali, E. Vinnars. Departments of Anesthesiology and Intensive Care, Huddinge University Hospital, and St Göran's Hospital, Stockholm, SwedenClinical Nutrition, 1987
- A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscleFEBS Letters, 1987
- The effect of stress hormones on the interorgan flux of amino acids and on the concentration of free amino acids in skeletal muscleClinical Nutrition, 1985
- Changes in muscle and plasma amino acid metabolism in severe malnutrition — The influence of total parenteral nutritionClinical Nutrition, 1985
- Metabolic effects of four intravenous nutritional regimens in patients undergoing elective surgery II.—Muscle amino acids and energy-rich phosphatesClinical Nutrition, 1983
- Influence of Injury and Nutrition on Muscle Water and ElectrolytesAnnals of Surgery, 1981
- The Influence of Abdominal Surgical Trauma Upon the Turnover of Some Blood‐Borne Energy Metabolites in the Human LegJournal of Parenteral and Enteral Nutrition, 1981
- Plasma amino acid concentrations in surgical patientsJournal of Parenteral and Enteral Nutrition, 1980