Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity
- 30 May 2016
- journal article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 17 (7), 806-815
- https://doi.org/10.1038/ni.3464
Abstract
The DNA methyltransferase Dnmt3a has not been studied in innate immunity. Cao and colleagues show that Dnmt3a enhances antiviral responses via a non-canonical mechanism to activate the kinase TBK1 and the production of type I interferons in macrophages.Keywords
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