Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes
- 23 July 2010
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 329 (5990), 444-448
- https://doi.org/10.1126/science.1190485
Abstract
Location, Location, Location: The genome receives epigenetic marks throughout development that regulate the activity of multiple genes. One such mark is methylation, which usually represses gene transcription. Methylation has generally been studied in the promoters of genes, where many regulatory signals coordinate to control the expression of the gene. Studying neural stem cells from mice, Wu et al. (p. 444 ) now show that DNA methylation can be a double-edged sword. Although methylation of DNA sequences in promoters tends to be repressive, methylation of DNA sequences beyond the promoters can actually promote gene expression. Analysis of the methyltransferase Dnmt3a in mouse neural stem cells revealed that methylations around neurogenic genes—but outside their promoters—maintained the activity of these genes.Keywords
This publication has 28 references indexed in Scilit:
- Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX–DNMT3–DNMT3L domainEMBO Reports, 2009
- Human DNA methylomes at base resolution show widespread epigenomic differencesNature, 2009
- Developmental programming of CpG island methylation profiles in the human genomeNature Structural & Molecular Biology, 2009
- The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shoresNature Genetics, 2009
- Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell lineProceedings of the National Academy of Sciences of the United States of America, 2008
- Genome-scale DNA methylation maps of pluripotent and differentiated cellsNature, 2008
- DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNANature, 2007
- Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genomeNature Genetics, 2007
- Glycosylation regulates Notch signallingNature Reviews Molecular Cell Biology, 2003
- Targeted mutation of the DNA methyltransferase gene results in embryonic lethalityCell, 1992