Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria
- 26 September 2004
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 5 (11), 1175-1180
- https://doi.org/10.1038/ni1123
Abstract
The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-positive bacterial species activate an immune response in a PGRP-SA- and GNBP1-independent manner, indicating that alternative receptors exist. Consistent with this, we noted that PGRP-SD mutants were susceptible to some Gram-positive bacteria and that a loss-of-function mutation in PGRP-SD severely exacerbated the PGRP-SA and GNBP1 mutant phenotypes. These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA–GNBP1 complex.Keywords
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