The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein

Abstract

The antimicrobial defence of Drosophila relies largely on the challenge-induced synthesis of an array of potent antimicrobial peptides by the fat body^1,2. The defence against Gram-positive bacteria and natural fungal infections is mediated by the Toll signalling pathway, whereas defence against Gram-negative bacteria is dependent on the Immune deficiency (IMD) pathway^{3,4,5,6,7,8,9,10,11,12,13,14,<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 15" title="Lu, Y., Wu, L. P. & Anderson,...}