Membranous nephropathy with monoclonal IgG4 deposits and associated IgG4-related lung disease
Open Access
- 25 July 2014
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Kidney Journal
- Vol. 7 (5), 475-478
- https://doi.org/10.1093/ckj/sfu077
Abstract
A 62-year-old woman was admitted for nephrotic syndrome and lung tumor. A renal biopsy showed membranous features of the glomeruli. Immunofluorescence studies revealed granular IgG4-κ deposits along with the glomerular basement membrane. Electron microscopy revealed granular electron-dense deposits. Further study denied multiple myeloma. Light microscopy of the resected lung tumor revealed IgG4-related lung disease with no malignancy. Steroid therapy induced a remission of the nephrotic syndrome, with no recurrence of the lung tumor. We consider that this is the first case of a proliferative glomerulonephritis with monoclonal IgG deposits of IgG4 subclass, and a rare concurrence with IgG4-related disease.Keywords
This publication has 13 references indexed in Scilit:
- Membranous glomerulonephritis is a manifestation of IgG4-related diseaseKidney International, 2013
- Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011Modern Rheumatology, 2012
- PLA2R Autoantibodies and PLA2R Glomerular Deposits in Membranous NephropathyNew England Journal of Medicine, 2011
- Proliferative Glomerulonephritis with Monoclonal IgG Deposits Recurs in the AllograftClinical Journal of the American Society of Nephrology, 2011
- Steroid-responsive nephrotic syndrome in a patient with proliferative glomerulonephritis with monoclonal IgG deposits with pure mesangial proliferative featuresClinical Kidney Journal, 2010
- An immunocompromised dialysis patient with skin and bone lesionsClinical Kidney Journal, 2010
- Proliferative Glomerulonephritis with Monoclonal IgG DepositsJournal of the American Society of Nephrology, 2009
- Characteristics of proliferative glomerulo-nephritis with monoclonal IgG deposits associated with membranoproliferative featuresClinical Nephrology, 2009
- Monoclonal immunoglobulin deposition disease associated with membranous featuresNephrology Dialysis Transplantation, 2008
- Proliferative glomerulonephritis with monoclonal IgG deposits: A distinct entity mimicking immune-complex glomerulonephritisKidney International, 2004