Steroid-responsive nephrotic syndrome in a patient with proliferative glomerulonephritis with monoclonal IgG deposits with pure mesangial proliferative features
Open Access
- 2 May 2010
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Kidney Journal
- Vol. 3 (4), 357-359
- https://doi.org/10.1093/ndtplus/sfq076
Abstract
A 78-year-old woman developed acute-onset nephrotic syndrome. A renal biopsy showed mild mesangial proliferative glomerulonephritis. Immunofluorescence studies revealed granular IgG3- λ deposits within the mesangial area and along the glomerular capillary walls. Electron microscopy showed mesangial and subendothelial granular electron-dense deposits. The pattern of deposition was predominantly mesangial. Serum or urine monoclonal proteins were not detected. Middle-dose steroid therapy induced a rapid remission of nephrotic syndrome. We consider that this is the first case of steroid-responsive nephrotic syndrome due to an extremely rare glomerular disease, proliferative glomerulonephritis with monoclonal IgG deposits associated with pure mesangial proliferative features.Keywords
This publication has 6 references indexed in Scilit:
- Proliferative Glomerulonephritis with Monoclonal IgG DepositsJournal of the American Society of Nephrology, 2009
- Characteristics of proliferative glomerulo-nephritis with monoclonal IgG deposits associated with membranoproliferative featuresClinical Nephrology, 2009
- Monoclonal immunoglobulin deposition disease associated with membranous featuresNephrology Dialysis Transplantation, 2008
- The ultrastructural basis of renal pathology in monoclonal gammopathies.2005
- Proliferative glomerulonephritis with monoclonal IgG deposits: A distinct entity mimicking immune-complex glomerulonephritisKidney International, 2004
- Monoclonal immunoglobulin deposition disease (Randall type). Relationship with structural abnormalities of immunoglobulin chainsKidney International, 1994