Long term uricosuric therapy in gout

Abstract

The effectiveness of long term uricosuric therapy was evaluated in sixty-four patients with primary gout. Serum uric acid was reduced to normal in half the patients; the majority manifested a urate diuresis. In seventeen of fifty patients with tophi, these lesions decreased in size. Acute gouty attacks were reduced to less than one per year in forty-five, patients; the chronic symptoms present in fifty-one patients improved in forty., Effectiveness of therapy was categorized as good, moderate, and poor, with examples of illustrative cases.