Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes
- 1 January 1987
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 325 (6100), 125-130
- https://doi.org/10.1038/325125a0
Abstract
The genes encoding the alpha and beta chains of the T-cell receptor (Ti) of an antigen-specific, Ia-restricted murine T-cell hybridoma were introduced into T3-positive or T3-negative human T cells. The resultant transfectants express either mouse-human or mouse-mouse Ti alpha beta molecules functionally associated with the human T3 complex. Only the complete murine Ti alpha beta dimer mediates specific functional corecognition of the appropriate antigen-Ia pair.Keywords
This publication has 31 references indexed in Scilit:
- A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytesNature, 1986
- Identification of a putative second T-cell receptorNature, 1986
- Functional expression of the murine Thy-1.2 gene in transfected human T cells.The Journal of Experimental Medicine, 1986
- Identification of the components of the murine T cell antigen receptor complexCell, 1985
- The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segmentsNature, 1985
- Reconstitution of an active surface T3/T-cell antigen receptor by DNA transferNature, 1985
- Identification of antigen receptor-associated structures on murine T cellsNature, 1985
- A third type of murine T-cell receptor geneNature, 1984
- A third rearranged and expressed gene in a clone of cytotoxic T lymphocytesNature, 1984
- Functional expression of a transfected murine class II MHC geneNature, 1983