Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer
- 1 August 1985
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 316 (6029), 606-609
- https://doi.org/10.1038/316606a0
Abstract
We have introduced a full-length complementary DNA of the T-cell antigen receptor β-chain into a mutant human T-cell line that lacked a complete β-chain messenger RNA, had a diminished level of α-chain transcript and did not express surface T3- or antigen receptor. Expression of the transfected β-chain led to a normal level of α-chain transcript and a structurally and functionally active T3 T-cell antigen receptor complex on the cell surface.This publication has 37 references indexed in Scilit:
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