DNA topoisomerases as targets for anticancer drugs
Open Access
- 1 December 2001
- journal article
- research article
- Published by Hindawi Limited in Journal of Clinical Pharmacy & Therapeutics
- Vol. 26 (6), 405-416
- https://doi.org/10.1046/j.1365-2710.2001.00368.x
Abstract
DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth. Over the past few years there has been considerable pharmacological interest in these enzymes because inhibitors of DNA topoisomerases represent a major class of anticancer drugs. This review highlights topoisomerase‐targeting drugs that have shown promising anticancer activities. The mechanisms by which those drugs interfere with the catalytic cycles of type I and type II DNA topoisomerases and the factors involved in the development of resistance to these drugs are discussed.Keywords
This publication has 53 references indexed in Scilit:
- Investigating the biological functions of DNA topoisomerases in eukaryotic cellsBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998
- Structure and mechanism of DNA topoisomerase IINature, 1996
- Effect of genistein on topoisomerase activity and on the growth of [VAL 12]Ha-ras-transformed NIH 3T3 cellsBiochemical and Biophysical Research Communications, 1988
- Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA.Proceedings of the National Academy of Sciences of the United States of America, 1985
- Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.Proceedings of the National Academy of Sciences of the United States of America, 1984
- Qualitative and quantitative aspects of intercalator-induced DNA strand breaksBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1979
- Protein-associated DNA breaks in cells treated with adriamycin or ellipticineBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1978
- Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.Proceedings of the National Academy of Sciences of the United States of America, 1976
- Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2Journal of the American Chemical Society, 1966
- 1,8-Naphthyridine Derivatives. A New Class of Chemotherapeutic AgentsJournal of Medicinal Chemistry, 1962