Mitochondrial DNA Control Region Polymorphism in the Population of Alagoas State, North-Eastern Brazil
- 1 January 2008
- journal article
- Published by Wiley in Journal of Forensic Sciences
- Vol. 53 (1), 142-146
- https://doi.org/10.1111/j.1556-4029.2007.00619.x
Abstract
The sequences of the two hypervariable (HV) segments of the mitochondrial DNA (mtDNA) control region were determined in 167 randomly selected, unrelated individuals living in the state of Alagoas, north‐eastern Brazil. One hundred and forty‐five different haplotypes, associated with 139 variable positions, were determined. More than 95% of the mtDNA sequences could be allocated to specific mtDNA haplogroups according to the mutational motifs. Length heteroplasmy in the C‐stretch HV1 and HV2 regions was observed in 22 and 11%, respectively, of the population sample. The genetic diversity was estimated to be 0.9975 and the probability of two random individuals presenting identical mtDNA haplotypes was 0.0084. The most frequent haplotype was shared by six individuals. All sequences showed high‐quality values and phantom mutations were not detected. The diversity revealed in the mitochondrial control region indicates the importance of this locus for forensic casework and population studies within Alagoas, Brazil.Keywords
This publication has 21 references indexed in Scilit:
- Phantom mutation hotspots in human mitochondrial DNAElectrophoresis, 2005
- A call for mtDNA data quality control in forensic scienceForensic Science International, 2004
- The Fingerprint of Phantom Mutations in Mitochondrial DNA DataAmerican Journal of Human Genetics, 2002
- The Ancestry of Brazilian mtDNA LineagesAmerican Journal of Human Genetics, 2000
- Validation of mitochondrial DNA sequencing for forensic casework analysisInternational journal of legal medicine, 1995
- Molecular Genetic Analyses of the Tyrolean Ice ManScience, 1994
- The application of mitochondrial DNA typing to the study of white Caucasian genetic identificationInternational journal of legal medicine, 1993
- Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cellsJournal of Cellular Physiology, 1988
- Intraspecific nucleotide sequence variability surrounding the origin of replication in human mitochondrial DNAGene, 1983
- Sequence and organization of the human mitochondrial genomeNature, 1981