Locked Nucleic Acids: Promising Nucleic Acid Analogs for Therapeutic Applications
- 15 March 2010
- journal article
- review article
- Published by Wiley in Chemistry & Biodiversity
- Vol. 7 (3), 536-542
- https://doi.org/10.1002/cbdv.200900343
Abstract
Locked Nucleic Acid (LNA) is a unique nucleic‐acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid‐based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides for controlling gene expression.This publication has 52 references indexed in Scilit:
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