Medial Temporal Lobe Atrophy, Apolipoprotein Genotype, and Plasma Homocysteine in Sri Lankan Patients with Alzheimer's Disease
- 1 July 2005
- journal article
- research article
- Published by Informa UK Limited in Experimental Aging Research
- Vol. 31 (3), 345-354
- https://doi.org/10.1080/03610730590948221
Abstract
The authors studied the association of Alzheimer's disease (AD) with total plasma homocysteine (tHcy) and apolipoprotein E (apoE) genotype, and the usefulness of measuring medial temporal lobe thickness (MTL) thickness for the diagnosis of AD in Sri Lankan patients. Using criteria of the NINCDS-ADRDA, 23 AD patients and 21 controls were recruited. All underwent MTL-oriented computed tomographic (CT) scans, measurement of plasma tHcy, and apoE genotyping. Mean plasma tHcy was significantly higher in AD patients than controls (p = .001). This association was independent of age, sex, body mass index (BMI), serum folate and vitamin B12, and serum creatinine. The frequency of apoE4 allele was significantly higher (p = .003) in AD patients, and the adjusted odds ratio of AD for the presence of one or more apoE4 alleles compared with none was 10.39 (95% CI 1.77–61.10; p = .010). The mean minimum MTL thickness was significantly higher in control subjects compared to that of AD patients (p < .001). This first report of apoE4, plasma tHcy, MTL thickness, and AD from Sri Lanka shows that high plasma tHcy, the presence of apoE4 allele, and MTL atrophy are associated with AD.Keywords
This publication has 31 references indexed in Scilit:
- Caregivers of people with Alzheimer's disease: a qualitative study from the Indian 10/66 Dementia Research NetworkInternational Journal of Geriatric Psychiatry, 2002
- Mini Mental State Examination in Sinhalese: a sensitive test to screen for dementia in Sri LankaInternational Journal of Geriatric Psychiatry, 2002
- Plasma Total Homocysteine and Cognitive Performance in a Volunteer Elderly PopulationAnnals of the New York Academy of Sciences, 2000
- Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer DiseaseArchives of Neurology, 1998
- Prevalence of Alzheimer's disease and other dementias in rural IndiaNeurology, 1998
- Apolipoprotein E ϵ4 and Incidence of Alzheimer Disease in a Community Population of Older PersonsPublished by American Medical Association (AMA) ,1997
- In Vivo Structural Studies of the Hippocampus in Normal Aging and in Incipient Alzheimer's DiseaseaAnnals of the New York Academy of Sciences, 1996
- Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset FamiliesScience, 1993
- EARLY MARKER FOR ALZHEIMER'S DISEASE: THE ATROPHIC HIPPOCAMPUSThe Lancet, 1989
- Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementiaActa Neuropathologica, 1977