Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia
- 1 January 1977
- journal article
- research article
- Published by Springer Science and Business Media LLC in Acta Neuropathologica
- Vol. 37 (2), 111-118
- https://doi.org/10.1007/bf00692056
Abstract
The number of pyramidal neurones in the hippocampal cortex was determined in serially sectioned mesial temporal lobe from brains of 18 mentally normal people; as well as those of 8 demented patients with pathologically confirmed Alzheimer's disease. Normal ageing was accompanied by a gradual loss of neurones, whereas dements' brains showed a much more severe decrease, exceeding that of controls at any age. A high degree of negative exponential correlation was found between the density of neurones/mm3 of cortex and both the number of neurones with neurofibrillary degeneration and the number with granulovacuolar degeneration. The functional significance of the latter changes is thus probably greater than previously assumed, given the diminished population of surviving neurones in which these alterations appear. Both tangles and granulovacuoles demonstrated a stronger propensity for occurring in the posterior half of the hippocampus in demented patients' brains. This would not have been predicted from the relative distribution of neuronal loss in the two halves. The posterior portion of the hippocampus may be considerably more susceptible to the degenerative nerve cell changes prominent in dementia of the Alzheimer type.This publication has 15 references indexed in Scilit:
- GRANULOVACUOLAR DEGENERATION IN THE AGEING BRAIN AND IN DEMENTIAJournal of Neuropathology and Experimental Neurology, 1977
- NEUROFIBRILLARY TANGLES AND THE PATHOGENESIS OF DEMENTIA: A QUANTITATIVE STUDYNeuropathology and Applied Neurobiology, 1976
- VARIATIONS IN THE HUMAN PURKINJE CELL POPULATION ACCORDING TO AGE AND SEXNeuropathology and Applied Neurobiology, 1975
- ‘NEURONAL FALL-OUT’ IN THE AGEING BRAIN: A CRITICAL REVIEW OF THE QUANTITATIVE DATAAge and Ageing, 1974
- The cerebral cortex in presenil dementiaActa Neuropathologica, 1973
- Observations on the brains of demented old peopleJournal of the Neurological Sciences, 1970
- Quantitative histological studies on the aged human brainActa Neuropathologica, 1970
- The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly SubjectsThe British Journal of Psychiatry, 1968
- CLINICOPATHOLOGIC SIGNIFICANCE OF GRANULOVACUOLAR DEGENERATION IN ALZHEIMERʼS DISEASEJournal of Neuropathology and Experimental Neurology, 1962
- Organization of the cerebral cortex. III. A study of aging in the human cerebral cortexJournal of Comparative Neurology, 1955