Polymorphisms in Genes Involved in Inflammatory Pathways in Patients with Sudden Sensorineural Hearing Loss
- 5 March 2012
- journal article
- Published by Informa UK Limited in Journal of Neurogenetics
- Vol. 26 (3-4), 387-396
- https://doi.org/10.3109/01677063.2011.652266
Abstract
Although the etiology of idiopathic sudden sensorineural hearing loss (SSNHL) remains unclear, the pathologically increased permeability of blood vessels, elucidated by gadolinium-enhanced magnetic resonance imaging (MRI), suggests the involvement of inflammation. Because SSNHL is considered a multifactorial disease, possibly caused by interactions between genetic factors and environmental factors, the authors investigated the associations of polymorphisms of inflammatory mediator genes with susceptibility to SSNHL. The authors compared 72 patients affected by SSNHL and 2010 adults (1010 men and 1000 women; mean age 59.2 years; range 40–79) who participated in the National Institute for Longevity Sciences Longitudinal Study of Aging. Multiple logistic regression was used to obtain odds ratios (ORs) for SSNHL in subjects with polymorphisms in the genes IL-6 C − 572G, IL-4R G1902A, IL-10 A − 592C, TNFα C − 863A, TNFRSF1B G593A, VEGF C936T, VEGF C − 2578A, and VEGF G − 1154A, with adjustment for age, gender, and any history of hypertension, diabetes, or dyslipidemia. The per-allele OR for the risk of SSNHL in subjects bearing IL-6 C − 572G was 1.480 (95% confidence interval [CI], 1.037–2.111) in model 1 (no adjustment), 1.463 (CI, 1.022–2.094) in model 2 (adjusted for age and gender), and 1.460 (CI, 1.016–2.097) in model 3 (adjusted for age, gender, and a history of hypertension, diabetes, or dyslipidemia). Under the dominant model of inheritance, the ORs were 1.734 (CI, 1.080–2.783) in model 1, 1.690 (CI, 1.050–2.721) in model 2, and 1.669 (CI, 1.035–2.692) in model 3. The remaining seven polymorphisms failed to show any associations with the risk of SSNHL. These data need to be confirmed on larger series of patients. In conclusion, the IL-6 C − 572G polymorphism is associated with a risk of SSNHL. Because permeability of blood vessels in the inner ear is frequently increased in patients with SSNHL, inflammation of the inner ear might be involved.Keywords
This publication has 32 references indexed in Scilit:
- Contribution of 1425G/A Polymorphism in Protein Kinase C-Eta (PRKCH) Gene and Brain White Matter Lesions to the Risk of Sudden Sensorineural Hearing Loss in a Japanese Nested Case-Control StudyJournal of Neurogenetics, 2011
- Expression of the proinflammatory cytokines in cochlear explant cultures: Influence of normoxia and hypoxiaNeuroscience Letters, 2010
- Cardiovascular and Thromboembolic Risk Factors in Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control StudyAudiology and Neurotology, 2010
- Sudden sensorineural hearing lossThe Lancet, 2010
- Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with sudden sensorineural hearing lossThe Laryngoscope, 2010
- Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trialAnnals of Oncology, 2009
- Genetic and Acquired Prothrombotic Risk Factors and Sudden Hearing LossThe Laryngoscope, 2007
- Proinflammatory cytokines expression in noise-induced damaged cochleaJournal of Neuroscience Research, 2006
- IL4 receptor polymorphism is associated with increased risk of sudden deafness in Korean populationLife Sciences, 2006
- Evaluation of Prostaglandin E1 Therapy for Sudden DeafnessThe Laryngoscope, 1989