Addressing insulin resistance in Type 1 diabetes
- 29 August 2008
- journal article
- review article
- Published by Wiley in Diabetic Medicine
- Vol. 25 (9), 1015-1024
- https://doi.org/10.1111/j.1464-5491.2008.02493.x
Abstract
Type 1 diabetes is recognised to include an element of insulin resistance. Insulin resistance is an independent risk factor for the development of macro- and microvascular complications of Type 1 diabetes and may also contribute to the development of the disease. This understanding comes at a time when the incidence of Type 1 diabetes appears to be rising and the public health burden from its vascular complications is high. A variety of safe and efficacious manoeuvres are available to redress insulin resistance in Type 2 diabetes. So far however, clinical trials addressing insulin resistance in Type 1 diabetes have been small with only short periods of follow-up. Regardless, these trials have yielded promising results. This review examines the evidence for insulin resistance in the pathophysiology of Type I diabetes and its complications, the problems associated with its measurement, and summarizes the trials aimed at reducing insulin resistance in Type I diabetes. This includes a meta-analysis of controlled trials of adjuvant metformin in Type I diabetes.Keywords
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