Prevention of chronic cerebral vasospasm in dogs with ibuprofen and high-dose methylprednisolone.
- 1 August 1989
- journal article
- abstracts
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 20 (8), 1021-1026
- https://doi.org/10.1161/01.str.20.8.1021
Abstract
Severe chronic cerebral vasospasm was produced in dog basilar arteries by two injections, 2 days apart, of autologous blood into the cisterna magna of 25 dogs. Treatment with ibuprofen (n = 8) or high-dose methylprednisolone (n = 8) after the first injection of blood prevented or reduced angiographic vasospasm. Cerebrospinal fluid concentrations of prostaglandin E2, prostaglandin F2 alpha, 6-ketoprostaglandin F1 alpha (a metabolite of prostacyclin), and thromboxane B2 (a metabolite of thromboxane A2) were measured in both treated and untreated (n = 7) dogs. In untreated dogs, the level of prostaglandin E2 increased 94-fold by Day 8 after the first injection of blood and was strongly and positively correlated with the degree of angiographic vasospasm. Treatment with ibuprofen and high-dose methylprednisolone prevented or significantly reduced this increase in prostaglandin E2 concentration. Smaller increases in cerebrospinal fluid concentrations of thromboxane B2 and 6-ketoprostaglandin F1 alpha occurred after experimental subarachnoid hemorrhage; the magnitude of these increases was also reduced by ibuprofen or high-dose methylprednisolone treatment. In contrast, prostaglandin F2 alpha levels were not significantly altered during the study. These data show that enhanced prostaglandin E2 synthesis occurs during experimental subarachnoid hemorrhage, and the by-products generated in its synthesis may play a role in the pathogenesis of cerebral vasospasm.This publication has 17 references indexed in Scilit:
- Activation of the Arachidonate 5‐Lipoxygenase Pathway in the Canine Basilar Artery After Experimental Subarachnoidal HemorrhageJournal of Neurochemistry, 1988
- The role of the prostacyclin-thromboxane system in cerebral vasospasm following induced subarachnoid hemorrhage in the rabbitJournal of Neurosurgery, 1984
- Effects of prostacyclin and indomethacin on experimental delayed cerebral vasospasmJournal of Neurosurgery, 1983
- Delayed cerebral vasospasm is not reversible by aminophylline, nifedipine, or papaverine in a “two-hemorrhage” canine modelJournal of Neurosurgery, 1983
- Comparison of Piroxicam, Meclofenamate, Ibuprofen, Aspirin, and Prostacyclin Efficacy in a Chronic Model of Cerebral VasospasmNeurosurgery, 1983
- Cerebral arterial constriction after experimental subarachnoid hemorrhage is associated with blood components within the arterial wallJournal of Neurosurgery, 1983
- Role of Prostaglandins and Arachidonic Acid Derivatives in the Coupling of Cerebral Blood Flow to Cerebral MetabolismJournal of Cerebral Blood Flow & Metabolism, 1981
- Prostaglandin metabolism in experimental cerebral vasospasmJournal of Neurosurgery, 1981
- Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generationNature, 1979
- IbuprofenDrugs, 1971