Effects of prostacyclin and indomethacin on experimental delayed cerebral vasospasm
- 1 November 1983
- journal article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 59 (5), 829-834
- https://doi.org/10.3171/jns.1983.59.5.0829
Abstract
Isolated canine basilar artery contracted by prostaglandin E2, hemoglobin, or serum was relaxed in a dose-dependent manner by the addition of 10(-8)M to 10(-6)M prostacyclin (PGI2), and was scarcely relaxed by 10(-9)M PGI2. In other studies, intravenous administration of PGI2 (25 or 75 ng/kg/min), indomethacin (4 mg/kg), or indomethacin (4 mg/kg) plus PGI2 (25 ng/kg/min) failed to reverse angiographic delayed vasospasm produced in vivo in the canine basilar artery by an intracisternal injection of blood. In addition, no significant increase occurred in mean values of regional cerebral blood flow (rCBF) with any treatments, and mean rCBF difference in dogs treated by PGI2 infusion at 25 ng/kg/min was 2.5 +/- 1.2 ml/100 gm/min and only significantly increased (p less than 0.01). Mean arterial blood pressure was significantly reduced by PGI2 infusion at 25 (p less than 0.05) or 75 ng/kg/min (p less than 0.005).Keywords
This publication has 30 references indexed in Scilit:
- Prostacyclin and cerebral vessel relaxationJournal of Neurosurgery, 1982
- Prostaglandin metabolism in experimental cerebral vasospasmJournal of Neurosurgery, 1981
- The effect of indomethacin on cerebral blood flow and oxygen consumption in the rat at normal and increased carbon dioxide tensionsActa Physiologica Scandinavica, 1981
- Mechanism of cerebral arterial contraction induced by blood constituentsJournal of Neurosurgery, 1980
- Prostaglandin I2 and indomethacin prevent impairment of post-ischemic brain reperfusion in the dog.Stroke, 1979
- A double blind placebo controlled crossover study of prostacyclin in manLife Sciences, 1979
- Responses of baboon cerebral and extracerebral arteries to prostacyclin and prostaglandin endoperoxide in vitro and in vivo.Journal of Neurology, Neurosurgery & Psychiatry, 1979
- In vitro assay of contractile activities of spastic canine basilar artery and its surrounding blood clotJournal of Neurosurgery, 1979
- Indomethacin prevents impaired perfusion of the dogs's brain after global ischemia.Stroke, 1978
- Responses of isolated dog cerebral and peripheral arteries to prostaglandins after application of aspirin and polyphloretin phosphate.Stroke, 1978