Motilin and Gastrin Secretion and Lipid Profile in Preterm Neonates Following Prebiotics Supplementation
- 14 November 2013
- journal article
- research article
- Published by Wiley in Journal of Parenteral and Enteral Nutrition
- Vol. 39 (3), 359-368
- https://doi.org/10.1177/0148607113510182
Abstract
Background: Gut hormones play an important role in the adaptation of the immature neonatal gut, and their secretion may be modulated by prebiotics. Furthermore, prebiotics are well known for their hypolipidemic potentials. We tested the hypothesis that prebiotics could alter motilin and gastrin secretion and reduce lipids in healthy preterms. Methods: A total of 167 newborns were randomized to either a prebiotics enriched formula containing dietary oligosaccharides (short-chain galacto-oligo-saccharides/long-chain fructo-oligo-saccharides [scGOS/lcFOS]), at a concentration of 0.8 g/100 ml, or a common preterm formula. Day 1 and 16 basal motilin, gastrin concentrations, and lipids were evaluated together with growth parameters, gastric residue, bowel habits, and feeding tolerance. Adverse events including necrotizing enterocolitis (NEC) and septicemia were also recorded. Results: Mean motilin increase and day 16 mean values were greater for the intervention, compared with the control group (P = .001, P = .005, respectively), while gastrin remained high in both groups. Mean cholesterol and low density lipoprotein (LDL) increase were significantly greater in the control, compared with the intervention (P = .037, and P = .001) group. Day 16 LDL levels were significantly higher in the control group. Mean weight was increased in the control group, while gastric residue was less and stool frequency was increased in the intervention group. NEC and septicemia were not statistically different between groups. Conclusion: A prebiotics enriched formula resulted in significant surge of motilin relating to reduced gastric residue, compared with a common preterm formula. Mean cholesterol change was lower, while LDL was not increased in the prebiotics group, compared with the control group.Keywords
This publication has 48 references indexed in Scilit:
- Growth Curves: How to Best Measure Growth of the Preterm InfantThe Journal of Pediatrics, 2013
- Effects of Prebiotic‐Containing Infant Formula on Gastrointestinal Tolerance and Fecal Microbiota in a Randomized Controlled TrialJournal of Parenteral and Enteral Nutrition, 2012
- Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodentsAmerican Journal of Physiology-Endocrinology and Metabolism, 2008
- Perinatal and Neonatal Manipulation of the Intestinal Microbiome: A Note of CautionNutrition Reviews, 2008
- Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseasesDrug Discovery Today, 2008
- Motilin activates neurons in the rat amygdala and increases gastric motilityPeptides, 2007
- Prebiotic oligosaccharides reduce stool viscosity and accelerate gastrointestinal transport in preterm infantsActa Paediatrica, 2006
- Increase of faecal bifidobacteria due to dietary oligosaccharides induces a reduction of clinically relevant pathogen germs in the faeces of formula‐fed preterm infantsActa Paediatrica, 2005
- Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight NeonatesThe Journal of Pediatrics, 2005
- Plasma gastrin and somatostatin levels in newborn infants receiving supplementary formula feedingActa Paediatrica, 1994