Effects of Prebiotic‐Containing Infant Formula on Gastrointestinal Tolerance and Fecal Microbiota in a Randomized Controlled Trial
- 11 January 2012
- journal article
- research article
- Published by Wiley in Journal of Parenteral and Enteral Nutrition
- Vol. 36 (1S), 95S-105S
- https://doi.org/10.1177/0148607111430087
Abstract
Background: Prebiotic‐containing infant formula may beneficially affect gastrointestinal tolerance and commensal microbiota composition. Objective: Assess gastrointestinal tolerance and fecal microbiota, pH, and short‐chain fatty acid (SCFA) concentrations of infants consuming formula with or without prebiotics. Design: Full‐term formula‐fed infants were studied to a breastfed comparison group (BF). Formula‐fed infants (FF) were randomized to consume a partially hydrolyzed whey formula with (PRE) or without (CON) 4 g/L of galacto‐oligosaccharides and fructo‐oligosaccharides (9:1). Fecal bacteria, pH, and SCFA were assessed at baseline, 3 weeks, and 6 weeks. Caregivers of patients recorded stool characteristics and behavior for 2 days before the 3‐ and 6‐week visits. Results: Feces from infants fed PRE had a higher absolute number (P = .0083) and proportion (P = .0219) of bifidobacteria than CON‐fed infants and did not differ from BF. BF had a higher proportion of bifidobacteria than CON (P = .0219) and lower number of Clostridium difficile than FF (P = .0087). Feces from formula‐fed infants had higher concentrations of acetate (P < .001), butyrate (P < .001), propionate (P < .001), and total SCFAs (P = .0230) than BF; however, fecal pH was lower (P = .0161) in PRE and BF than CON. Prebiotic supplementation did not alter stool patterns, tolerance, or growth. BF had more frequent stools that were yellow (P < .0001) and more often liquid than FF (P < .0001). Conclusions: Infant formula containing the studied oligosaccharides was well tolerated, increased abundance and proportion of bifidobacteria, and reduced fecal pH in healthy infants.This publication has 46 references indexed in Scilit:
- Term Infants Fed Formula Supplemented With Selected Blends of Prebiotics Grow Normally and Have Soft Stools Similar to Those Reported for Breast‐fed InfantsJournal of Pediatric Gastroenterology and Nutrition, 2007
- A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of ageArchives of Disease in Childhood, 2006
- Increase of faecal bifidobacteria due to dietary oligosaccharides induces a reduction of clinically relevant pathogen germs in the faeces of formula‐fed preterm infantsActa Paediatrica, 2005
- Prebiotic effects of a wheat germ preparation in human healthy subjectsFood Microbiology, 2004
- Human milk is a source of lactic acid bacteria for the infant gutThe Journal of Pediatrics, 2003
- Effects of a new mixture of prebiotics on faecal flora and stools in term infantsActa Paediatrica, 2003
- Clostridium perfringens in stool, intraparturn antibiotics and gastrointestinal signs in a neonatal intensive care unitActa Paediatrica, 1994
- Effects of the in vitro fermentation of oligofructose and inulin by bacteria growing in the human large intestineJournal of Applied Bacteriology, 1993
- The Effect of "Humanised" Milks and Supplemented Breast Feeding on The Faecal Flora of InfantsJournal of Medical Microbiology, 1977
- Breast Milk Substitute: A Bacteriological StudyBMJ, 1973