Antimalarial Bromophycolides J−Q from the Fijian Red Alga Callophycus serratus
- 9 March 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 74 (7), 2736-2742
- https://doi.org/10.1021/jo900008w
Abstract
Bromophycolides J−Q (1−8) were isolated from extracts of the Fijian red alga Callophycus serratus and identified with 1D and 2D NMR spectroscopy and mass spectral analyses. These diterpene−benzoate macrolides represent two novel carbon skeletons and add to the 10 previously reported bromophycolides (9−18) from this alga. Among these 18 bromophycolides, several exhibited activities in the low micromolar range against the human malaria parasite Plasmodium falciparum.Keywords
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