Sex-Specific Assembly of a Dosage Compensation Complex on the Nematode X Chromosome
- 6 December 1996
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 274 (5293), 1736-1739
- https://doi.org/10.1126/science.274.5293.1736
Abstract
In nematodes, flies, and mammals, dosage compensation equalizes X-chromosome gene expression between the sexes through chromosome-wide regulatory mechanisms that function in one sex to adjust the levels of X-linked transcripts. Here, a dosage compensation complex was identified in the nematode Caenorhabditis elegans that reduces transcript levels from the two X chromosomes in hermaphrodites. This complex contains at least four proteins, including products of the dosage compensation genes dpy-26 and dpy-27. Specific localization of the complex to the hermaphrodite X chromosomes is conferred by XX-specific regulatory genes that coordinately control both sex determination and dosage compensation.Keywords
This publication has 14 references indexed in Scilit:
- DPY-26, a Link Between Dosage Compensation and Meiotic Chromosome Segregation in the NematodeScience, 1996
- VIVE LA DIFFÉRENCE: Males vs Females in Flies vs WormsAnnual Review of Genetics, 1996
- The SMC family: from chromosome condensation to dosage compensationCurrent Opinion in Cell Biology, 1995
- The SMC proteins and the coming of age of the chromosome scaffold hypothesisBioEssays, 1995
- SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family.Genes & Development, 1995
- DPY-27: A chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosomeCell, 1994
- SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family.The Journal of cell biology, 1993
- Independent domains of the Sdc-3 protein control sex determination and dosage compensation in C. elegansCell, 1993
- xol-1: A gene that controls the male modes of both sex determination and X chromosome dosage compensation in C. elegansCell, 1988
- sdc-1: A link between sex determination and dosage compensation in C. elegansCell, 1987