Parent proxy–reported health‐related quality of life and fatigue in pediatric patients diagnosed with brain tumors and acute lymphoblastic leukemia
Open Access
- 18 October 2004
- Vol. 101 (9), 2116-2125
- https://doi.org/10.1002/cncr.20609
Abstract
BACKGROUND Pediatric patients with brain tumors (BT) are often excluded from health-related quality of life (HRQOL) studies even though they experience more severe disease and treatment-related sequelae than children with other types of cancer. Parent proxy assessments of HRQOL allow for greater inclusion of children who are developmentally immature, physically ill, or cognitively impaired. METHODS Parents of children ages 2–18 years who were diagnosed at Childrens Hospital Los Angeles and Children's Hospital San Diego with BT (n = 86) or acute lymphoblastic leukemia (ALL; n = 170) evaluated their children's HRQOL over the previous week using the parent-proxy versions of the Pediatric Quality of Life Inventory (PedsQL™) 4.0 Generic Core scales, the PedsQL™ 3.0 Acute Cancer Module, and the PedsQL™ Multidimensional Fatigue scales. Multiple regression analyses were used to determine the independent effect of the child's diagnosis on HRQOL. Separate analyses were conducted for patients receiving treatment, patients who had not received treatment for < 12 months, and patients who had not received treatment for ≥ 12 months. RESULTS Patients with BT exhibited more problems than patients with ALL in the physical, social, psychosocial, school, cognitive, and fatigue domains of HRQOL. The Core Physical Health, Core Psychosocial Health, and Fatigue Total scores for patients with BT demonstrated peak improvements for children who had not received treatment for < 12 months and sharp declines for children who had not received treatment for ≥ 12 months. The Core Physical Health and Fatigue Total scores for patients with ALL were highest (better HRQOL) for those who had not received treatment for ≥ 12 months. CONCLUSIONS Pediatric patients and survivors of BT experienced more fatigue and HRQOL problems than patients with ALL, and HRQOL differed by treatment status. Cancer 2004. © 2004 American Cancer Society.Keywords
This publication has 19 references indexed in Scilit:
- Psychological Outcomes in Long-Term Survivors of Childhood Brain Cancer: A Report From the Childhood Cancer Survivor StudyJournal of Clinical Oncology, 2004
- Health Status of Adult Long-term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor StudyJAMA, 2003
- The value of the PedsQLTM in assessing quality of life in survivors of childhood cancerChild: Care, Health and Development, 2003
- Psychosocial and behavioral functioning among pediatric brain tumor survivors.Journal of Neuro-Oncology, 2003
- The PedsQL™ in pediatric cancerCancer, 2002
- Memory Deficits among Children with CraniopharyngiomasNeurosurgery, 2001
- Medical and neurocognitive late effects among survivors of childhood central nervous system tumorsCancer, 2001
- Long-term neurobehavioral outcome in pediatric brain-tumor patients: Review and methodological critiqueJournal of Clinical and Experimental Neuropsychology, 1994
- Preliminary design of six major river pipeline crossings in permafrost terrain. Conference. Preprint.International Journal of Rock Mechanics and Mining Sciences, 1975
- Coefficient alpha and the internal structure of testsPsychometrika, 1951