Psychological Outcomes in Long-Term Survivors of Childhood Brain Cancer: A Report From the Childhood Cancer Survivor Study
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- 15 March 2004
- journal article
- research article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 22 (6), 999-1006
- https://doi.org/10.1200/jco.2004.06.148
Abstract
Purpose To evaluate and compare psychological outcomes in long-term survivors of pediatric brain cancer and siblings of childhood cancer survivors, and to identify significant correlates of psychological distress. Methods One thousand one hundred one adult survivors of childhood brain cancer and 2,817 siblings completed a long-term follow-up questionnaire allowing assessment of symptoms associated with depression, somatization, and anxiety, as well as demographic, health, and medical information. Results A large majority of siblings and survivors report few, if any, symptoms of psychological distress. The prevalence of distress approximating clinically significant levels for both survivors (11%) and siblings (5%) reflects rates found in the general population. Yet when accounting for significant sociodemographic, socioeconomic, and health-status variables, survivors of childhood brain cancer, in the aggregate, appear to report significantly higher global distress and depression scores than do siblings. As in the general population, higher levels of distress among survivors and siblings were associated with female sex, low household income, lower educational attainment, being unmarried, not being employed in the past 12 months, and poor physical health status. No diagnostic or treatment-related variables were directly and significantly associated with increases in distress symptoms for survivors of childhood brain cancer. Conclusion Cancer treatment does not appear to contribute directly to increased psychological distress. Instead, distress appears to be associated with diminished social functioning that may be related to cancer type or treatment. Implementation and evaluation of supportive interventions that enhance survivors' social and vocational skills should be considered.Keywords
This publication has 17 references indexed in Scilit:
- Endocrine and cardiovascular late effects among adult survivors of childhood brain tumorsCancer, 2003
- New evidence on the relationship between income and healthJournal of Health Economics, 1996
- Follow-up and quality of survival of 67 consecutive children with CNS tumorsChild's Nervous System, 1994
- Quality of long-term survival in young children with medulloblastomaJournal of Neurosurgery, 1994
- Long-term neurobehavioral outcome in pediatric brain-tumor patients: Review and methodological critiqueJournal of Clinical and Experimental Neuropsychology, 1994
- Returning to Primary School After Treatment for CancerPediatric Hematology and Oncology, 1994
- Scale for assessing quality of life of children survivors of cranial posterior fossa tumorsJournal of Neuro-Oncology, 1994
- Factors Associated with Social and Behavioral Problems Among Children Recently Diagnosed with Brain TumorJournal of Pediatric Psychology, 1993
- Pretreatment Neuropsychological Status and Associated Factors in Children with Primary Brain TumorsNeurosurgery, 1990
- A new look at the statistical model identificationIEEE Transactions on Automatic Control, 1974