Inhibition of Species of the Aspergillus Section Nigri and Ochratoxin A Production in Grapes by Fusapyrone
- 1 April 2008
- journal article
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 74 (7), 2248-2253
- https://doi.org/10.1128/aem.01998-07
Abstract
Fusapyrone (FP), an antifungal natural compound, was tested against the three main ochratoxigenic species of the Aspergillus section Nigri . The MICs at 24 h were 6.0, 11.6, and 9.9 μg/ml for Aspergillus carbonarius , Aspergillus tubingensis , and Aspergillus niger , respectively. Strong inhibition of growth and morphological changes were still observed at half the MIC after 7 days. The application of a 100 μg/ml FP solution in a laboratory assay on artificially inoculated grapes resulted in a significant reduction (up to 6 orders of magnitude) of A. carbonarius CFU counts. Dramatic reductions of the ochratoxin A (OTA) content, compared to the content of the positive control (average amount of OTA, 112.5 ng/g of grape; three experiments), were obtained with the application of either 100 or 50 μg/ml of FP (0.6 or 5.1 ng/g of grape, respectively).This publication has 37 references indexed in Scilit:
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