Cytotoxic and proinflammatory effects of ambient and source-related particulate matter (PM) in relation to the production of reactive oxygen species (ROS) and cytokine adsorption by particles
- 10 December 2010
- journal article
- Published by Informa UK Limited in Inhalation Toxicology
- Vol. 22 (sup2), 37-47
- https://doi.org/10.3109/08958378.2010.518377
Abstract
The composition of airborne particulate matter (PM) varies widely depending on its source, and recent studies have suggested that particle-associated adverse health effects are related to particle composition. The objective of this study was to compare the biological/toxicological effects of different source-related PM. Specifically, we investigated the biological/toxicological effects of standard reference materials (SRMs): non-ferrous dust (PD-1, industrial), urban PM (UPM, SRM1648a), and diesel PM (DPM, SRM2975), and ambient PM2.5 (PM with an aerodynamic diameter 1000 µg/ml for the SRM1648a, SRM2975, and ambient PM2.5). Similarly, the PM-induced release of IL-8 was greatest for PD-1 (~6–9 ng/ml vs. ~1.5–3 ng/ml for others). These endpoints were more responsive to metals as compared with compared with secondary inorganic ions and organic compounds. Interestingly, we demonstrated a high degree of adsorption of IL-8 to the various SRMs and ambient PM2.5, and subsequently derived a new correction method to aid in interpretation of these data. These characteristics likely impart differential effects toward the toxic and immune effects of PM.Keywords
This publication has 42 references indexed in Scilit:
- Determination of metal-based hydroxyl radical generating capacity of ambient and diesel exhaust particlesInhalation Toxicology, 2009
- Environmentally persistent free radicals amplify ultrafine particle mediated cellular oxidative stress and cytotoxicityParticle and Fibre Toxicology, 2009
- Redox activity of airborne particulate matter at different sites in the Los Angeles BasinEnvironmental Research, 2005
- Seasonal Variations in Air Pollution Particle-Induced Inflammatory Mediator Release and Oxidative StressEnvironmental Health Perspectives, 2005
- Air pollution: the "Heart" of the problem.Current Hypertension Reports, 2003
- RESPONSE OF HUMAN ALVEOLAR MACROPHAGES TO ULTRAFINE, FINE, AND COARSE URBAN AIR POLLUTION PARTICLESExperimental Lung Research, 2003
- Air Pollution from Traffic and the Development of Respiratory Infections and Asthmatic and Allergic Symptoms in ChildrenAmerican Journal of Respiratory and Critical Care Medicine, 2002
- Particulate Matter Induces Cytokine Expression in Human Bronchial Epithelial CellsAmerican Journal of Respiratory Cell and Molecular Biology, 2001
- Similar cellular effects induced by diesel exhaust particles from a representative diesel vehicle recovered from filters and Standard Reference Material 1650Toxicology in Vitro, 2001
- An Association between Air Pollution and Mortality in Six U.S. CitiesThe New England Journal of Medicine, 1993