Primary nasal natural killer cell lymphoma: long-term treatment outcome and relationship with the International Prognostic Index
Top Cited Papers
- 1 January 2004
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 103 (1), 216-221
- https://doi.org/10.1182/blood-2003-05-1401
Abstract
Nasal natural killer (NK) cell lymphoma is rare, so that its optimal therapy, long-term outcome, and prognostic factors are unclear. Data on 52 men and 15 women with well-characterized nasal NK cell lymphomas were analyzed retrospectively to define the impact of primary therapy on remission and long-term outcome and the validity of the International Prognostic Index (IPI). Most (84%) had stage I/II disease with an IPI score of 1 or less (52%). Seven patients received radiotherapy only; 47 patients received anthracycline-containing chemotherapy plus consolidation radiotherapy; and 12 patients received nonanthracycline-containing chemotherapy plus radiotherapy. The overall complete remission (CR) rate was 64.2%; the 20-year overall survival (OS) and disease-free survival (DFS) rates were 37.1% and 33.5%, respectively. Front-line radiotherapy was apparently better than chemotherapy for CR (100% versus 59%, P = .04) and OS (83.3% versus 32.0%, P = .03). Relapses occurred in 4 radiotherapy-treated (all local) and 14 chemotherapy-treated patients (9 local, 4 systemic). Among these, 5 late relapses (4 local, 1 systemic) occurred at 170 months (range, 92-348 months) from CR. The IPI score was of prognostic significance for the whole group (IPI ≤ 1 superior to IPI ≥ 2 for 20-year OS: 57.4% versus 27.6%, P = 0.012), as well as for patients treated with chemotherapy/radiotherapy (IPI ≤ 1 superior to IPI ≥ 2 for CR: 76.7% versus 35.7%, P = .017; and 10-year OS: 63.8% versus 26.8%, P = .003).This publication has 40 references indexed in Scilit:
- p53 Mutations in Nasal Natural Killer/T-Cell Lymphoma from Mexico: Association with Large Cell Morphology and Advanced DiseaseThe American Journal of Pathology, 2001
- Sinonasal LymphomaThe American Journal of Surgical Pathology, 1999
- Lymphoma of the nasal cavity and paranasal sinusesCancer, 1997
- CD56+ NK lymphomas:clinicopathological features and prognosisBritish Journal of Haematology, 1997
- Autologous bone marrow transplantation for primary nasal T/NK cell lymphomaBone Marrow Transplantation, 1997
- Clinicopathologic study of nasal T/NK‐cell lymphoma among the JapanesePathology International, 1997
- Treatment of Lethal Midline Granuloma Type Nasal T-Cell LymphomaActa Oncologica, 1997
- PRESENCE OF EPSTEIN‐BARR VIRUS DNA IN NASAL LYMPHOMAS OF B AND ‘T’ CELL TYPEHematological Oncology, 1990
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958