Regulation of Autophagy by Glucose in Mammalian Cells
Open Access
- 27 July 2012
- Vol. 1 (3), 372-395
- https://doi.org/10.3390/cells1030372
Abstract
Autophagy is an evolutionarily conserved process that contributes to maintain cell homeostasis. Although it is strongly regulated by many extracellular factors, induction of autophagy is mainly produced by starvation of nutrients. In mammalian cells, the regulation of autophagy by amino acids, and also by the hormone insulin, has been extensively investigated, but knowledge about the effects of other autophagy regulators, including another nutrient, glucose, is more limited. Here we will focus on the signalling pathways by which environmental glucose directly, i.e., independently of insulin and glucagon, regulates autophagy in mammalian cells, but we will also briefly mention some data in yeast. Although glucose deprivation mainly induces autophagy via AMPK activation and the subsequent inhibition of mTORC1, we will also comment other signalling pathways, as well as evidences indicating that, under certain conditions, autophagy can be activated by glucose. A better understanding on how glucose regulates autophagy not only will expand our basic knowledge of this important cell process, but it will be also relevant to understand common human disorders, such as cancer and diabetes, in which glucose levels play an important role.This publication has 176 references indexed in Scilit:
- Invisible emotional expressions influence social judgments and pupillary responses of both depressed and non-depressed individualsFrontiers in Psychology, 2013
- mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTORMolecular Cell, 2011
- DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and AutophagyMolecular Cell, 2011
- Autophagy in the Cellular Energetic BalanceCell Metabolism, 2011
- Relationship Between Amygdala Responses to Masked Faces and Mood State and Treatment in Major Depressive DisorderArchives of General Psychiatry, 2010
- 2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletionCancer Chemotherapy and Pharmacology, 2010
- Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with SupplyMolecular Cell, 2010
- mTOR regulation of autophagyFEBS Letters, 2010
- Turnover of organelles by autophagy in yeastCurrent Opinion in Cell Biology, 2009
- p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR SignalingCell, 2008