Lily bulbs’ polyphenols extract ameliorates oxidative stress and lipid accumulation in vitro and in vivo
- 11 February 2021
- journal article
- research article
- Published by Wiley in Journal of the Science of Food and Agriculture
- Vol. 101 (12), 5038-5048
- https://doi.org/10.1002/jsfa.11148
Abstract
BACKGROUND Polyphenols have the potential to reduce the risk of many metabolic disorders. Lily bulbs are rich in polyphenols; however, their effects on lipid metabolism remain unclear. This study aimed to explore the effects of lily bulbs’ polyphenols (LBPs) on oxidative stress and lipid metabolism. RESULTS A total of 14 polyphenolic compounds in LBPs were identified by high‐performance liquid chromatography equipped with diode‐array detection mass spectrometry. Total phenolic compound in LBPs was 53.76 ± 1.12 g kg−1 dry weight. In cellular experiments, LBPs attenuated the disruption of mitochondrial membrane potential, impeded reactive oxygen species production, alleviated oxidative stress, and reduced lipid accumulation in oleic acid induced HepG2 cells. In in vivo studies, LBPs significantly inhibited body weight gain, reduced lipid levels in serum and liver, and improved oxidative damage in a dose‐dependent manner in mice fed a high‐fat diet. Moreover, LBPs ameliorated hepatic steatosis and suppressed the expression of hepatic‐lipogenesis‐related genes (SREBP‐1c, FAS, ACC1, and SCD‐1) and promoted lipolysis genes (SRB1 and HL) and lipid oxidation genes (PPARα and CPT‐1) in mice fed a high‐fat diet. CONCLUSION It was concluded that LBPs are a potential complementary therapeutic alternative in the development of functional foods to curb obesity and obesity‐related diseases, such as metabolic syndrome. © 2021 Society of Chemical IndustryKeywords
Funding Information
- National Natural Science Foundation of China
This publication has 53 references indexed in Scilit:
- Extracts of Pomelo Peels Prevent High-Fat Diet-Induced Metabolic Disorders in C57BL/6 Mice through Activating the PPARα and GLUT4 PathwayPLOS ONE, 2013
- Nuclear Factor (Erythroid-Derived 2)-Like-2 Factor (Nrf2), a Key Regulator of the Antioxidant Response to Protect Against Atherosclerosis and Nonalcoholic SteatohepatitisCurrent Diabetes Reports, 2013
- Green Tea Polyphenols Reduced Fat Deposits in High Fat-Fed Rats via erk1/2-PPARγ-Adiponectin PathwayPLOS ONE, 2013
- Preparative separation of phenylpropenoid glycerides from the bulbs of Lilium lancifolium by high-speed counter-current chromatography and evaluation of their antioxidant activitiesFood Chemistry, 2012
- Anti-inflammatory effects of methanol extracts of the root of Lilium lancifolium on LPS-stimulated Raw264.7 cellsJournal of Ethnopharmacology, 2010
- Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletionBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
- Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leavesJournal of Pharmaceutical and Biomedical Analysis, 2009
- SREBPs: the crossroads of physiological and pathological lipid homeostasisTrends in Endocrinology & Metabolism, 2008
- HPLC−DAD−ESIMS Analysis of Phenolic Compounds in Nectarines, Peaches, and PlumsJournal of Agricultural and Food Chemistry, 2001
- Lipid and steroidal constituents of Lilium auratum var. Platyphyllum AND L. tenuifoliumPhytochemistry, 1989